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Since 2010 Luperini Group is a consolidated, dynamic and organized structure to interface with the pharmaceutical industry and other important sectors of industrial production.

Made in excellence made in Luperini

The three brands Luperini Tailored Pharma Machinery, Luperini Qualified Pharma Service and Luperini Qualified Tech & Service operate on a shared ground made of technological know-how, strong innovative drive, research of the highest quality of product and service, willingness to customize solutions.

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Luperini Brands dedicated to the pharma industry capitalize on the historical competence of a team with strong experience in this sector.

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Luperini – Tailored Pharma Machinery

The Tailored Pharma Machinery proposes customized technologies with great affordability and accuracy.

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Luperini Qualified Pharma Service

Luperini Qualified Pharma Service gives a complete range of excellent services: revamping and validation of existing machines and installations, spare parts and consulting, as well as ordinary and extraordinary maintenance.

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Luperini Qualified Tech & Service offers an articulated service activity for the integration, maintenance and installation of production plants for different industrial sectors, among which the Tissue one stands out.

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Luperini – Qualified Tech Service

Thanks to a facility of 5000 sqm, Luperini Qualified Tech & Service is able to offer customers a highly qualified service of pre-assembly of plants as well as carry out inspections and tests to secure the customers’ investment.

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Cognitive Pharma Machinery: The Revolution In The Pharmaceutical Industry Begins.

When a machine learns a production process and does so using its ‘senses’, finding its own way to continuous improvement, and does things that even the engineers who gave birth to it would not have imagined… well then the term ‘revolution’ is not used out of context. It may sound like the opening of a science fiction book but it is not. Cognitive Pharma Machinery exists. Today.

The language to follow will be more technical, forgive us, it was a must, but to get an idea of the extraordinariness of what is happening it is useful to get to the bottom of it.

This new technology combines Luperini’s experience in designing and manufacturing machinery and Eigengran‘s expertise in developing advanced control systems using IIoT sensors (image spectroscopy and haptic sensors) and artificial intelligence (AI) algorithms. The algorithms are based on self-learning neural networks (Deep Reinforcement Learning) that analyse and interpret data in real time to build predictive control models. This results in machines that can improve their control strategies over time by demonstrating cognitive capabilities.

The technology conforms to Process Analytical Technology (PAT) guidelines, facilitating the implementation of Quality by Design (QbD) in the pharmaceutical manufacturing process and representing a practical embodiment of Pharma 4.0, the pharmaceutical industry’s fourth industrial revolution.

Luperini has a new test centre in Chiesina Uzzanese, Italy, where the cognitive pilot machines can be tested. This offers the opportunity to gain first-hand experience of the technology and assess its potential.

Marco Luperini, CTO of Luperini:

Our technology is a key element in the application of PAT guidelines for oral drug production and will be a key step towards achieving pharma 4.0 practice in the pharmaceutical manufacturing process


Massimo Lungone, CEO of Luperini, added that

“We are proud to announce the successful development and testing of the Cognitive Pharma Machinery. Our partnership with Eigengran has enabled us to create a technology that will revolutionise the pharmaceutical industry”.


Carolina Gastone, CEO of Eigengran, adds:

We believe that this innovative technology will have a significant impact on the pharmaceutical industry and improve product quality and safety”.


The partnership between Luperini and Eigengran is committed to providing innovative solutions to the pharmaceutical industry. The development of Cognitive Pharma Machinery is a significant step towards achieving this goal.

Luperini Production S.p.A. & Eigengran S.r.l.





Luperini is a leading manufacturer of tailored-made pharmaceutical machinery for drugs in solid dosage form, including HSWG-type wet granulators and complete handling systems for powder and granular products. Through its commitment to quality, flexibility and innovation, the company aims to help customers achieve greater efficiency, precision and savings in their production processes.

Eigengran is an innovative start-up company developing advanced control systems based on artificial intelligence algorithms and predictive control. The company aims to embrace the transformation of artificial intelligence by harnessing its capabilities at the intersection of data-driven methods, applied optimisation and the classical fields of engineering and physics to advance knowledge in the field of particle technology and granulation technologies in particular.